Pulmonary expression of CXC chemokine ligand 13, CC chemokine ligand 19, and CC chemokine ligand 21 is essential for local immunity to influenza.

Nasal-Associated Lymphoid Tissue the Organization and Function of Chemokine Ligand (CCL) 19, and CCL21 in Role of CXC Chemokine Ligand 13, CC

B Cells + CD 5 + CD 23 Acute and Chronic Lymphocytic Leukemia Resistance to Apoptosis in B Cell Lineage Chemokine Ligand 19 Cooperatively Render CXC Chemokine Ligand 13 and CC

Altered expression of the receptor-ligand pair CXCR5/CXCL13 in B cells during chronic HIV-1 infection.

HIV-1 infection is associated with B-cell abnormalities, such as hypergammaglobulinemia, poor immunization responses, and loss of serologic memory. To determine whether altered expression of chemokine receptors and their ligands may play a role in B-cell dysfunctions during HIV-1 infection, the expression of CXC chemokine receptor 4 (CXCR4), CXCR5, and CC chemokine receptor 7 (CCR7) and their r...

Cutting edge: profile of chemokine receptor expression on human plasma cells accounts for their efficient recruitment to target tissues.

We systematically examined the repertoire of chemokine receptors expressed by human plasma cells. Fresh bone marrow plasma cells and myeloma cells consistently expressed CXCR4, CXCR6, CCR10, and CCR3. Accordingly, plasma cells responded to their respective ligands in chemotaxis and very late Ag-4-dependent cell adhesion to fibronectin. Immobilized CXC chemokine ligand (CXCL)16, a novel transmem...

Role of lymphotoxin-alpha in cigarette smoke-induced inflammation and lymphoid neogenesis.

In chronic obstructive pulmonary disease (COPD), chronic inflammation is accompanied by peribronchial lymphoid aggregates. Lymphotoxin (LT)-alpha, crucial in secondary lymphoid organogenesis, may be involved in lymphoid neogenesis. We examined cigarette smoke (CS)-induced pulmonary lymphoid neogenesis and inflammation in vivo in LTalpha knockout (LTalpha(-/-)) and wild-type (WT) mice and studie...